Soar, JasmeetBöttiger, Bernd WCarli, PierreJiménez, Francesc CarmonaCimpoesu, DianaCole, GarethCouper, KeithD'Arrigo, SoniaDeakin, Charles DEk, Jacqueline EleonoraHolmberg, Mathias JMagliocca, AuroraNikolaou, NikolaosPaal, PeterPocock, HelenSandroni, ClaudioScquizzato, TommasoSkrifvars, Markus BVerginella, FrancescaYeung, JoyceNolan, Jerry P2025-11-192025-11-192025-10Soar J, Böttiger BW, Carli P, Jiménez FC, Cimpoesu D, Cole G, Couper K, D'Arrigo S, Deakin CD, Ek JE, Holmberg MJ, Magliocca A, Nikolaou N, Paal P, Pocock H, Sandroni C, Scquizzato T, Skrifvars MB, Verginella F, Yeung J, Nolan JP. European Resuscitation Council Guidelines 2025 Adult Advanced Life Support. Resuscitation. 2025 Oct;215 Suppl 1:110769. doi: 10.1016/j.resuscitation.2025.110769.1873-157010.1016/j.resuscitation.2025.11076941117572S0300-9572(25)00281-3https://westmid.openrepository.com/handle/20.500.14200/9091These European Resuscitation Council (ERC) Guidelines 2025 Adult Advanced Life Support (ALS) are based on the International Liaison Committee on Resuscitation (ILCOR) Consensus on Cardiopulmonary Resuscitation Science with Treatment Recommendations (CoSTR). The evidence informing the ALS Guidelines is also included. When ILCOR has not addressed a specific topic, the ERC ALS Writing Group has provided its own guidance and the evidence supporting it. This section provides recommendations for ALS for adults with in- or out-of-hospital cardiac arrest. The ERC Guidelines 2025 ALS emphasise providing early and effective ALS interventions to improve survival from cardiac arrest in adults.enCopyright © 2025 European Resuscitation Council. Published by Elsevier B.V. All rights reserved.Hospital rapid response teamHeart arrestAdvanced cardiac life supportGuideline