Buono, AndreaBasavarajaiah, SandeepChoudhury, AnirbanLee, LeongBhatia, GurbirHailan, AhmedSharma, VinodaUPADHYAYA, SUBRAMANYANaneishvili, TamaraIelasi, Alfonso2024-01-112024-01-112021-07-02Buono, A., Basavarajaiah, S., Choudhury, A., Lee, L., Bhatia, G., Hailan, A., Sharma, V., Upadhyaya, S., Naneishvili, T., & Ielasi, A. (2022). "RotaTripsy" for Severe Calcified Coronary Artery Lesions: Insights From a Real-World Multicenter Cohort. Cardiovascular revascularization medicine : including molecular interventions, 37, 78–81.1878-093810.1016/j.carrev.2021.06.13234244087http://hdl.handle.net/20.500.14200/3353Objectives: The aim of this study is to assess the feasibility, efficacy and safety of the "RotaTripsy" approach in severe calcified coronary artery lesions. Background: Coronary lesions with a high calcium content represent a challenging scenario in interventional cardiology, requiring a proper lesion preparation. In this light, very little is known about the possibility to combine the benefits of rotational atherectomy and intravascular lithotripsy. Methods: We retrospectively enrolled 34 patients from a real-word, multicenter, cohort of patients affected by severe calcified coronary artery lesions, which required the "RotaTripsy" to obtain a proper lesion preparation. In all the cases, rotational atherectomy and then intravascular lithotripsy were performed as a bail-out strategy following sub-optimal non-compliant balloon expansion. In 53% of the cases, the procedure was guided by intracoronary imaging findings. Results: Procedural success was reported in all the cases, without any in-hospital major complication. Few major adverse clinical events were reported at mid-term follow-up. Conclusions: "RotaTripsy" can represent a valid therapeutic option for undilatable heavily calcified coronary artery lesions. Our findings demonstrate the feasibility, safety and efficacy of this approach.enCopyright © 2021 Elsevier Inc. All rights reserved.CardiologyArticle