Zhu, ZhuotingWang, YueyeQi, ZiyiHu, WenyiZhang, XiayinWagner, Siegfried KWang, YujieRan, An RanOng, JoshuaWaisberg, EthanMasalkhi, MouayadSuh, AlexTham, Yih ChungCheung, Carol YYang, XiaohongYu, HonghuaGe, ZongyuanWang, WeiSheng, BinLiu, YunLee, Andrew GDenniston, Alastair KWijngaarden, Peter vanKeane, Pearse ACheng, Ching-YuHe, MingguangWong, Tien Yin2025-10-282025-10-282025-03-04Zhu Z, Wang Y, Qi Z, Hu W, Zhang X, Wagner SK, Wang Y, Ran AR, Ong J, Waisberg E, Masalkhi M, Suh A, Tham YC, Cheung CY, Yang X, Yu H, Ge Z, Wang W, Sheng B, Liu Y, Lee AG, Denniston AK, Wijngaarden PV, Keane PA, Cheng CY, He M, Wong TY. Oculomics: Current concepts and evidence. Prog Retin Eye Res. 2025 May;106:101350. doi: 10.1016/j.preteyeres.2025.101350. Epub 2025 Mar 4.1350-94621873-163510.1016/j.preteyeres.2025.10135040049544S1350-9462(25)00023-0https://westmid.openrepository.com/handle/20.500.14200/8856The eye provides novel insights into general health, as well as pathogenesis and development of systemic diseases. In the past decade, growing evidence has demonstrated that the eye's structure and function mirror multiple systemic health conditions, especially in cardiovascular diseases, neurodegenerative disorders, and kidney impairments. This has given rise to the field of oculomics-the application of ophthalmic biomarkers to understand mechanisms, detect and predict disease. The development of this field has been accelerated by three major advances: 1) the availability and widespread clinical adoption of high-resolution and non-invasive ophthalmic imaging ("hardware"); 2) the availability of large studies to interrogate associations ("big data"); 3) the development of novel analytical methods, including artificial intelligence (AI) ("software"). Oculomics offers an opportunity to enhance our understanding of the interplay between the eye and the body, while supporting development of innovative diagnostic, prognostic, and therapeutic tools. These advances have been further accelerated by developments in AI, coupled with large-scale linkage datasets linking ocular imaging data with systemic health data. Oculomics also enables the detection, screening, diagnosis, and monitoring of many systemic health conditions. Furthermore, oculomics with AI allows prediction of the risk of systemic diseases, enabling risk stratification, opening up new avenues for prevention or individualized risk prediction and prevention, facilitating personalized medicine. In this review, we summarise current concepts and evidence in the field of oculomics, highlighting the progress that has been made, remaining challenges, and the opportunities for future research.enCopyright © 2025 The Authors. Published by Elsevier Ltd.. All rights reserved.Artificial intelligenceEyeDiagnostic imagingOphthalmologyArticle