Less social deprivation Is associated with better health-related quality of life in asthma and is mediated by less anxiety and better sleep quality.

Show simplified metadata
dc.contributor.authorMoitra, Subhabrata
dc.contributor.authorAdan, Ana
dc.contributor.authorAkgün, Metin
dc.contributor.authorAnderson, Augustus
dc.contributor.authorBrickstock, Amanda
dc.contributor.authorEathorne, Allie
dc.contributor.authorFarshchi Tabrizi, Ali
dc.contributor.authorHaldar, Prasun
dc.contributor.authorHenderson, Linda
dc.contributor.authorJindal, Aditya
dc.contributor.authorJindal, Surinder Kumar
dc.contributor.authorKerget, Bugra
dc.contributor.authorKhadour, Fadi
dc.contributor.authorMelenka, Lyle
dc.contributor.authorMoitra, Saibal
dc.contributor.authorMoitra, Tanusree
dc.contributor.authorMukherjee, Rahul
dc.contributor.authorSemprini, Alex
dc.contributor.authorTurner, Alice M
dc.contributor.authorMurgia, Nicola
dc.contributor.authorFerrara, Giovanni
dc.contributor.authorLacy, Paige
dc.contributor.departmentRespiratoryen_US
dc.contributor.roleMedical and Dentalen_US
dc.contributor.trustauthorMukherjee, Rahul
dc.contributor.trustauthorTurner, Alice M
dc.date.accessioned2023-06-16T13:19:43Z
dc.date.available2023-06-16T13:19:43Z
dc.date.issued2023-04-20
dc.description.abstractBackground: Previous studies on health-related quality of life (HRQoL) in asthma have mainly focused on clinical and environmental determinants. Little is known about the role of social determinants on HRQoL in asthma. Objectives: We aimed to investigate the association between social deprivation and HRQoL in asthma. Methods: A total of 691 adult asthmatics from Canada, India, New Zealand, and the United Kingdom were administered a digital questionnaire containing demographic information and questions about social and psychological attributes, sleep disturbances, and alcohol abuse. HRQoL was measured using the Short Form of the Chronic Respiratory Questionnaire (SF-CRQ). We analyzed the direct and indirect relationships between social deprivation and HRQoL using structural equation models with social deprivation as a latent variable. We tested for mediation via anxiety, depression, sleep disturbances, and alcohol abuse. Results: We found that less social deprivation (latent variable) was directly associated with better SF-CRQ domain scores such as dyspnea (regression coefficient β: 0.33; 95% confidence interval [CI]: 0.07 to 0.58), fatigue (β: 0.39; 95% CI: 0.14 to 0.64), and emotional function (β: 0.37; 95% CI: 0.11 to 0.62), but with the worse mastery score (β: -0.29; 95% CI: -0.55 to -0.03); however, those associations varied across participating countries. We also observed that among all individual social deprivation indicators, education, companionship, emotional support, instrumental support, and social isolation were directly associated with HRQoL, and the relationship between social deprivation and HRQoL was mediated through anxiety and sleep disturbances.en_US
dc.identifier.citationMoitra S, Adan A, Akgün M, Anderson A, Brickstock A, Eathorne A, Farshchi Tabrizi A, Haldar P, Henderson L, Jindal A, Jindal SK, Kerget B, Khadour F, Melenka L, Moitra S, Moitra T, Mukherjee R, Semprini A, Turner AM, Murgia N, Ferrara G, Lacy P. Less Social Deprivation Is Associated With Better Health-Related Quality of Life in Asthma and Is Mediated by Less Anxiety and Better Sleep Quality. J Allergy Clin Immunol Pract. 2023 Apr 20:S2213-2198(23)00407-5. doi: 10.1016/j.jaip.2023.03.052. Epub ahead of print.en_US
dc.identifier.doi10.1016/j.jaip.2023.03.052
dc.identifier.eissn2213-2201
dc.identifier.pmid37087095
dc.identifier.urihttp://hdl.handle.net/20.500.14200/1006
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.urlhttp://www.sciencedirect.com/science/journal/22132198en_US
dc.rightsCopyright © 2023 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.
dc.source.countryUnited States
dc.source.journaltitleJournal of Allergy and Clinical Immunology: In Practice
dc.subjectRespiratory medicineen_US
dc.subjectPsychologyen_US
dc.subjectDiseases & disorders of systemic, metabolic or environmental originen_US
dc.titleLess social deprivation Is associated with better health-related quality of life in asthma and is mediated by less anxiety and better sleep quality.en_US
dc.typeArticle
dspace.entity.typePublication
oa.grant.openaccessnaen_US
rioxxterms.versionNAen_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.7 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
UHB Respiratory