Community-based intervention for prevention and management of chronic obstructive pulmonary disease in Nepal (COBIN-P trial): study protocol for a cluster-randomized controlled trial.

Show simplified metadata
dc.contributor.authorAdhikari, Tara Ballav
dc.contributor.authorNeupane, Dinesh
dc.contributor.authorKarki, Arjun
dc.contributor.authorDrews, Arne
dc.contributor.authorCooper, Brendan
dc.contributor.authorHögman, Marieann
dc.contributor.authorSigsgaard, Torben
dc.contributor.authorKallestrup, Per
dc.contributor.departmentOutpatient Departmenten_US
dc.contributor.roleHealthcare Scientistsen_US
dc.contributor.trustauthorCooper, Brendan
dc.date.accessioned2024-07-19T15:11:58Z
dc.date.available2024-07-19T15:11:58Z
dc.date.issued2021-07-21
dc.description.abstractBackground: Chronic obstructive pulmonary disease (COPD) is one of the leading causes of death worldwide and the commonest of non-communicable diseases (NCDs) in Nepal. Risk factors like indoor and outdoor air pollution, a high prevalence of smoking, and the lack of awareness of COPD make it a serious public health concern. However, no attempt has been made in Nepal to estimate its burden and address the disease at the community level. Method: This study aims to evaluate the effect of a community-based health educational intervention administered by Female Community Health Volunteers (FCHVs) on the prevention and management of COPD. An open-label, two-group, community-based, cluster-randomized controlled trial will be implemented in the semi-urban area of Pokhara Metropolitan city (former Lekhnath Municipality) located in the Kaski district of Nepal. The estimated sample size of the intervention will be 1143. The unit of randomization is the ward (administrative unit) of the study area. The follow-up survey will be conducted immediately after 12 months of FCHVs-led interventions. The difference in the rate of decline of forced expiratory volume in 1 s (FEV1) and FEV1/FVC (forced vital capacity) ratio are the primary outcomes and the change in the proportion of modifiable risk factors of COPD, health-related quality of life scores, and change in knowledge of COPD will be secondary outcomes. Discussion: This study will estimate the burden of COPD, the magnitude of risk factors and generate evidence to mobilize community health workers for COPD prevention and management at the community level in Nepal. Trial registration: ClinicalTrials.gov NCT03797768 . Registered on January 9, 2019.en_US
dc.identifier.citationAdhikari TB, Neupane D, Karki A, Drews A, Cooper B, Högman M, Sigsgaard T, Kallestrup P. Community-based intervention for prevention and management of chronic obstructive pulmonary disease in Nepal (COBIN-P trial): study protocol for a cluster-randomized controlled trial. Trials. 2021 Jul 21;22(1):474. doi: 10.1186/s13063-021-05447-7en_US
dc.identifier.doi10.1186/s13063-021-05447-7
dc.identifier.eissn1745-6215
dc.identifier.pmid34289879
dc.identifier.urihttp://hdl.handle.net/20.500.14200/5199
dc.language.isoenen_US
dc.publisherBioMed Centralen_US
dc.relation.urlhttps://trialsjournal.biomedcentral.com/en_US
dc.rights© 2021. The Author(s).
dc.source.beginpage474
dc.source.countryEngland
dc.source.endpage
dc.source.issue1
dc.source.journaltitleTrialsen_US
dc.source.volume22
dc.subjectPublic health. Health statistics. Occupational health. Health educationen_US
dc.titleCommunity-based intervention for prevention and management of chronic obstructive pulmonary disease in Nepal (COBIN-P trial): study protocol for a cluster-randomized controlled trial.en_US
dc.typeArticleen_US
dspace.entity.typePublication
oa.grant.openaccessnaen_US
relation.isAuthorOfPublication977c160f-c69d-45b4-8b53-20ba8cde24fd
relation.isAuthorOfPublication.latestForDiscovery977c160f-c69d-45b4-8b53-20ba8cde24fd
rioxxterms.versionNAen_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.7 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
UHB Respiratory