The conjunctival extracellular matrix, related disorders and development of substrates for conjunctival restoration

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dc.contributor.affiliationSandwell and West Birmingham NHS Trust; University of Liverpool; Schepens Eye Research Institute, Mass Eye and Ear Infirmaryen_US
dc.contributor.authorMakuloluwa, Aruni K.
dc.contributor.authorHamill, Kevin J.
dc.contributor.authorRauz, Saaeha
dc.contributor.authorBosworth, Lucy
dc.contributor.authorHaneef, Atikah
dc.contributor.authorRomano, Vito
dc.contributor.authorWilliams, Rachel L.
dc.contributor.authorDartt, Darlene A.
dc.contributor.authorKaye, Stephen B.
dc.contributor.departmentSandwell West Birmingham NHS Trusten_US
dc.contributor.roleMedical and Dentalen_US
dc.contributor.trustauthorRauz, Saaeha
dc.date.accessioned2024-10-11T12:25:26Z
dc.date.available2024-10-11T12:25:26Z
dc.date.issued2023-04
dc.description.abstractThe conjunctiva can be damaged by numerous diseases with scarring, loss of tissue and dysfunction. Depending on extent of damage, restoration of function may require a conjunctival graft. A wide variety of biological and synthetic substrates have been tested in the search for optimal conditions for ex vivo culture of conjunctival epithelial cells as a route toward tissue grafts. Each substrate has specific advantages but also disadvantages related to their unique physical and biological characteristics, and identification and development of an improved substrate remains a priority. To achieve the goal of mimicking and restoring a biological material, requires information from the material. Specifically, extracellular matrix (ECM) derived from conjunctival tissue. Knowledge of the composition and structure of native ECM and identifying contributions of individual components to its function would enable using or mimicking those components to develop improved biological substrates. ECM is comprised of two components: basement membrane secreted predominantly by epithelial cells containing laminins and type IV collagens, which directly support epithelial and goblet cell adhesion differentiation and growth and, interstitial matrix secreted by fibroblasts in lamina propria, which provides mechanical and structural support. This review presents current knowledge on anatomy, composition of conjunctival ECM and related conjunctival disorders. Requirements of potential substrates for conjunctival tissue engineering and transplantation are discussed. Biological and synthetic substrates and their components are described in an accompanying review.en_US
dc.description.sponsorshipNational Institutes of Health
dc.identifier.citationMakuloluwa AK, Hamill KJ, Rauz S, Bosworth L, Haneef A, Romano V, Williams RL, Dartt DA, Kaye SB. The conjunctival extracellular matrix, related disorders and development of substrates for conjunctival restoration. Ocul Surf. 2023 Apr;28:322-335. doi: 10.1016/j.jtos.2021.05.011.en_US
dc.identifier.doi10.1016/j.jtos.2021.05.011
dc.identifier.issn1542-0124
dc.identifier.piiS1542012421000501
dc.identifier.urihttp://hdl.handle.net/20.500.14200/6108
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.rights© 2021 Elsevier Inc. All rights reserved.
dc.rights.uri
dc.source.beginpage
dc.source.endpage
dc.source.journaltitleen_US
dc.source.volume
dc.subjectOphthalmologyen_US
dc.titleThe conjunctival extracellular matrix, related disorders and development of substrates for conjunctival restorationen_US
dc.typeArticleen_US
dspace.entity.typePublication
oa.grant.openaccessnaen_US
rioxxterms.versionNAen_US
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