Moderate to severe acute migraine attacks: an opinion paper on the use of Triptans and Triptan-NSAIDs combinations in individualized treatment plans.

This opinion paper on the acute treatment of migraine addresses the definition and recognition of acute migraine attacks, highlighting the variety of symptoms and manifestations. It describes the available treatments and guidelines, noting significant country-specific variations. The paper also discusses the prescribers' knowledge and updates, recognizing the segment-specific differences. Despite nonsteroidal anti-inflammatory drugs (NSAIDs) and triptans being universally recommended as first-line treatments, their visibility in the field has diminished due to the promotion of newer medicines. The authors, a panel of 15 experts from six European countries, emphasize the underutilization of triptans and advocate for their prescription, and also their use in combination with NSAIDs, when NSAIDs alone are not sufficiently effective. The panel specifically considered the sumatriptan succinate-naproxen sodium combination, which was recently introduced in Europe and may be beneficial in patients not responding to NSAIDs, particularly for special patient groups, such as those with menstrual-related acute migraine or migraine attacks with prolonged pain or postdrome. Finally, the consensus highlights the need for individualized treatment plans and the importance of considering patient preferences and specific symptoms, integrating evidence-based recommendations with patient-centered care to optimize migraine management.

Citation

Goadsby PJ, Sinclair AJ, Afridi SK, Lucas C, Mawet J, Lanteri-Minet M, Moisset X, Diener HC, Gaul C, Jürgens TP, Sumelahti ML, Del Rio MS, Del Pozo-Rosich P, Russo A, Barbanti P. Moderate to Severe Acute Migraine Attacks: An Opinion Paper on the Use of Triptans and Triptan-NSAIDs Combinations in Individualized Treatment Plans. Neurol Ther. 2026 Feb;15(1):15-28. doi: 10.1007/s40120-025-00874-z. Epub 2025 Dec 18.

Type

Article