Refractory autoimmune hepatitis in children: considerations for assessment and management

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dc.contributor.authorValamparampil, Joseph
dc.contributor.authorBrown, Rachel M
dc.contributor.authorMcKiernan, Patrick
dc.contributor.departmentPathology
dc.contributor.roleMedical and Dental
dc.contributor.trustauthorBrown, Rachel
dc.date.accessioned2026-01-13T16:37:19Z
dc.date.available2026-01-13T16:37:19Z
dc.date.issued2025-12-27
dc.description.abstractRefractory autoimmune hepatitis (AIH) is defined as intolerance of or unresponsiveness to standard immunosuppression and occurs in 10%-20% of children with AIH. Lack of response or slower than expected response to induction of remission with steroids, despite good compliance, might be the first clue to refractory AIH. Refractoriness to treatment is associated with an 11.7 times higher risk for liver transplantation or death due to liver disease. The first and foremost consideration for the management is to assess compliance with treatment. It is then important to re-evaluate the diagnosis, assess alternative aetiologies which can mimic the clinical, serological, and histological features of AIH, and address the presence of extra-hepatic co-morbidities. It is important to consider the specific clinical situations, previous therapy, and prior adverse effects before deciding on the most appropriate treatment regimen in refractory AIH. Consideration also should be given to compliance with previous therapy, need for drug level monitoring, growth potential, available formulations, route of administration of medication, and children's and families' preferences before deciding on the therapy. Treatment should be decided and monitored only in specialized hepatology centers.
dc.identifier.citationPhillips R, Ma YT, Hanif W, Shah T, Sivakumar S. Nutrient-stimulated Hormone-based Therapies: A New Frontier in the Prevention and Management of MASH-associated Hepatocellular Carcinoma. J Clin Transl Hepatol. 2025 Dec 28;13(12):1060-1066. doi: 10.14218/JCTH.2025.00303. Epub 2025 Oct 22
dc.identifier.doi10.4254/wjh.v17.i12.110966
dc.identifier.issn1948-5182
dc.identifier.pmid41479508
dc.identifier.urihttps://westmid.openrepository.com/handle/20.500.14200/9410
dc.language.isoen
dc.publisherXia & He Publishing Inc
dc.rights©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
dc.source.beginpage110966
dc.source.countryUnited States
dc.source.issue12
dc.source.journaltitleWorld journal of hepatology
dc.source.volume17
dc.subjectHepatitis
dc.subjectPathology
dc.titleRefractory autoimmune hepatitis in children: considerations for assessment and management
dc.typeJournal Article
dspace.entity.typePublication
oa.grant.openaccessna
rioxxterms.versionNA
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