A reverse translational approach reveals the protective roles of Mangifera indica in inflammatory bowel disease.

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dc.contributor.authorSaviano, Anella
dc.contributor.authorSchettino, Anna
dc.contributor.authorIaccarino, Nunzia
dc.contributor.authorMansour, Adel Abo
dc.contributor.authorBegum, Jenefa
dc.contributor.authorMarigliano, Noemi
dc.contributor.authorRaucci, Federica
dc.contributor.authorRomano, Francesca
dc.contributor.authorRiccardi, Gelsomina
dc.contributor.authorMitidieri, Emma
dc.contributor.authord'Emmanuele di Villa Bianca, Roberta
dc.contributor.authorBello, Ivana
dc.contributor.authorPanza, Elisabetta
dc.contributor.authorSmimmo, Martina
dc.contributor.authorVellecco, Valentina
dc.contributor.authorRimmer, Peter
dc.contributor.authorCheesbrough, Jonathan
dc.contributor.authorZhi, Zhaogong
dc.contributor.authorIqbal, Tariq H
dc.contributor.authorPieretti, Stefano
dc.contributor.authorD'Amore, Vincenzo Maria
dc.contributor.authorMarinelli, Luciana
dc.contributor.authorLa Pietra, Valeria
dc.contributor.authorSorrentino, Raffaella
dc.contributor.authorCosta, Luisa
dc.contributor.authorCaso, Francesco
dc.contributor.authorScarpa, Raffaele
dc.contributor.authorCirino, Giuseppe
dc.contributor.authorRandazzo, Antonio
dc.contributor.authorBucci, Mariarosaria
dc.contributor.authorMcGettrick, Helen Michelle
dc.contributor.authorIqbal, Asif Jilani
dc.contributor.authorMaione, Francesco
dc.contributor.departmentGastroenterologyen_US
dc.contributor.roleMedical and Dentalen_US
dc.contributor.trustauthorBegum, Jenefa
dc.contributor.trustauthorIqbal, Tariq, H
dc.date.accessioned2024-04-09T13:01:49Z
dc.date.available2024-04-09T13:01:49Z
dc.date.issued2024-03-23
dc.description.abstractInflammatory bowel diseases (IBDs) are chronic intestinal disorders often characterized by a dysregulation of T cells, specifically T helper (Th) 1, 17 and T regulatory (Treg) repertoire. Increasing evidence demonstrates that dietary polyphenols from Mangifera indica L. extract (MIE, commonly known as mango) mitigate intestinal inflammation and splenic Th17/Treg ratio. In this study, we aimed to dissect the immunomodulatory and anti-inflammatory properties of MIE using a reverse translational approach, by initially using blood from an adult IBD inception cohort and then investigating the mechanism of action in a preclinical model of T cell-driven colitis. Of clinical relevance, MIE modulates TNF-α and IL-17 levels in LPS spiked sera from IBD patients as an ex vivo model of intestinal barrier breakdown. Preclinically, therapeutic administration of MIE significantly reduced colitis severity, pathogenic T-cell intestinal infiltrate and intestinal pro-inflammatory mediators (IL-6, IL-17A, TNF-α, IL-2, IL-22). Moreover, MIE reversed colitis-induced gut permeability and restored tight junction functionality and intestinal metabolites. Mechanistic insights revealed MIE had direct effects on blood vascular endothelial cells, blocking TNF-α/IFN-γ-induced up-regulation of COX-2 and the DP2 receptors. Collectively, we demonstrate the therapeutic potential of MIE to reverse the immunological perturbance during the onset of colitis and dampen the systemic inflammatory response, paving the way for its clinical use as nutraceutical and/or functional food. Keywords: CD4(+)CD45RB(high) colitis; Functional food; IBD; Mangifera indica L.; Nutraceuticals; Th17; Treg.en_US
dc.identifier.citationSaviano A, Schettino A, Iaccarino N, Mansour AA, Begum J, Marigliano N, Raucci F, Romano F, Riccardi G, Mitidieri E, d'Emmanuele di Villa Bianca R, Bello I, Panza E, Smimmo M, Vellecco V, Rimmer P, Cheesbrough J, Zhi Z, Iqbal TH, Pieretti S, D'Amore VM, Marinelli L, La Pietra V, Sorrentino R, Costa L, Caso F, Scarpa R, Cirino G, Randazzo A, Bucci M, McGettrick HM, Iqbal AJ, Maione F. A reverse translational approach reveals the protective roles of Mangifera indica in inflammatory bowel disease. J Autoimmun. 2024 Mar 23;144:103181. doi: 10.1016/j.jaut.2024.103181. Epub ahead of print. PMID: 38522129.en_US
dc.identifier.doi10.1016/j.jaut.2024.103181
dc.identifier.eissn1095-9157
dc.identifier.issn0896-8411
dc.identifier.pmid38522129
dc.identifier.urihttp://hdl.handle.net/20.500.14200/4135
dc.language.isoenen_US
dc.publisherAcademic Pressen_US
dc.rightsCopyright © 2024 Elsevier Ltd. All rights reserved.
dc.source.beginpage103181
dc.source.countryUnited Kingdom
dc.source.countryEngland
dc.source.endpage
dc.source.journaltitleJournal of Autoimmunity
dc.source.volume144
dc.subjectGastroenterologyen_US
dc.titleA reverse translational approach reveals the protective roles of Mangifera indica in inflammatory bowel disease.en_US
dc.typeArticle
dspace.entity.typePublication
oa.grant.openaccessnoen_US
rioxxterms.versionNAen_US
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